冯高谦

发布者:金沙威尼斯欢乐娱人城发布时间:2023-03-24浏览次数:3107

冯高谦,教授,博士,博士生导师,

科学研究方向

寄生虫感染与免疫

反向疫苗学

蚊媒病疫苗开发

联系方式

通讯:江苏省南京市江宁区龙眠大道101号病原生物学系,邮编211166

电邮:fenggaoqian@njmu.edu.cn


简介

冯高谦,博士,学院教授,博士生导师。主要从事包括疟原虫在内的寄生虫感染与宿主保护性免疫机制方面的研究,以及通过反向疫苗学开发新型疫苗等工作。曾主持澳大利亚NHMRC Ideas GrantCASS基金会Science and Medicine Grant,作为主要参与人参与多项PATH-MVI研究项目。近年来以第一作者在Nature CommunicationsBMC MedicineJournal of Infectious Diseases等高水平期刊发表多篇论文。目前按照Expert Scape排名,在所有疫苗方面的全球科学家中排名前0.2%。据Web of Science检索,H指数为19

 

教育背景及工作经历

2007-2011年 澳大利亚墨尔本大学医学院 博士

2011-2018年 澳大利亚Burnet医学研究所 Research Officer

2018-2023年 澳大利亚Burnet医学研究所 Senior Research Officer

2023-现在   学院病原生物系 教授

 

学术兼职

澳大利亚寄生虫学会 会员

世界卫生组织快速诊断试剂资格预评估专家

Frontiers in Cellular and Infection Microbiology 编委

Decoding Transmission and Infection 编委

中国寄生虫学与寄生虫病杂志青年编委

 

承担科研课题

1.    2020-2022  Harnessing host immunity against disease vectors      主持人   CASS Foundation

2.    2021-2022  Host immune mechanisms against disease vectors      主持人   Burnet Institute

3.    2018-2019  Understanding RTS,S immunity to inform vaccine implementation and design an improved pre-erythrocyte stage vaccine to facilitate malaria elimination   主持人   ACREME Seed Grant

4.2016-2017     Developing an effective vaccine against malaria that overcomes immune evasion    主持人   CASS Foundation

5.    2019-2022  Enhanced identification of targets of immunity to advance P. vivax vaccine development     共同主持人  Australian NHMRC Ideas Grant

 

代表性论文

1.  Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children Feng G, Kurtovic L, Agius P, itken E, Sacarlal J,. Wines B,   Hogarth P, Rogerson S, Fowkes F, Dobaño C and Beeson J  BMC Med 2022

2.  Mechanisms of Fc-receptor mediated immunity to malaria sporozoites. Feng, G., Wines, B. D., Kurtovic, L., Chan, J. A., Boeuf, P., Mollard, V., Cozijnsen, A., Drew, D. R., Center, R. J., Marshall, D. L., Chishimba, S., McFadden, G. I., Dent, A. E., Chelimo, K., Boyle, M. J., Kazura, J. W., Hogarth, P. M. and Beeson, J. G. Nat Commun 2021

3.  Human immunization with a polymorphic malaria vaccine candidate induced antibodies to conserved epitopes that promote functional antibodies to multiple parasite strains Feng, G., M. J. Boyle, N. Cross, J. A. Chan, L. Reiling, F. Osier, D. Stanisic, I. Mueller, R. F. Anders, J. S. McCarthy, J. S. Richards, and J. G. Beeson J Infect Dis  2018

4.  Targets of complement-fixing antibodies in protective immunity against malaria in children Reiling, L., M. J. Boyle, M. T. White, D. W. Wilson, G. Feng, R. Weaver, D. H. Opi, K. E. M. Persson, J. S. Richards, P. M. Siba, F. J. I. Fowkes, E. Takashima, T. Tsuboi, I. Mueller, and J. G. Beeson  Nat Commun 2019

5.  Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure Kurtovic, L., P. A. Agius, G. Feng, D. R. Drew, I. Ubillos, J. Sacarlal, J. J. Aponte, F. J. I. Fowkes, C. Dobano, and J. G. Beeson BMC Med 2019

6.  Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children Kurtovic, L., M. C. Behet, G. Feng, L. Reiling, K. Chelimo, A. E. Dent, I. Mueller, J. W. Kazura, R. W. Sauerwein, F. J. I. Fowkes, and J. G. Beeson BMC Med 2018

7.  CD14(hi)CD16+ monocytes phagocytose antibody- opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so. J Zhou, G Feng, J Beeson, PM Hogarth, SJ Rogerson, Y Yan, A Jaworowski. BMC Med.  2015

8.  Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria. MJ Boyle, L Reiling, G Feng, C Langer, FH Osier, H Aspeling-Jones, YS Cheng, J Stubbs, KK Tetteh, DJ Conway, JS McCarthy, I Muller, K Marsh, RF Anders, JG Beeson. Immunity.  2015

 

授权专利

James Beeson; Gaoqian Feng ; Liriye KURTOVIC ; Immunogenic compositions, 2022-2-10, WIPO, WO2022027107A1


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