李砚川

发布者:金沙威尼斯欢乐娱人城发布时间:2023-04-28浏览次数:4321

李砚川,教授,博士,博士生导师


科学研究方向

重要信号转导通路在免疫应答中的分子机理研究

 

联系方式

通讯:江苏省南京市江宁区龙眠大道101号学海楼细胞生物学系,邮编211166

电邮:liyanchuan@njmu.edu.cn


 

简介

金沙威尼斯欢乐娱人城细胞生物学系教授,博士生导师。长期从事重要信号转导通路在 B 细胞命运决定和免疫应答中的分子机理研究,已发表 16 篇国际权威期刊学术论文,其中近 5 年以第一作者或兼通讯作者发表 3 篇学术论文(Blood2021; Cell Research2019; Journal of Experimental Medicine2023)以及 13 篇共同第一或共同作者文章(包括 Nature Cell Biology2篇;Nature Medicine; Nature Immunology; Gastroenterology; Journal of Pineal Research; Nature Communications; Science Advances; Cell Reports; PNAS等)。代表性论文多次得到国际生物医学评论机构 Faculty Opinions ( F1000) 专家撰写专文推荐,并被 Nature 等权威期刊广泛引用。目前担任 Nucleic Acids Research, Molecular Therapy, Protein & Cell 等多个高水平学术期刊特邀评审人。

 

教育背景及工作经历

2012-2016  北京协和医学院 博士

2016-2021  美国德克萨斯大学MD安德森癌症中心 博士后

2021-2022  美国德克萨斯大学MD安德森癌症中心 研究科学家

2022-2023  美国贝勒医学院 副研究员

2023-至今   学院 教授

 

5年代表性论文 (通讯作者*)

1.           Li, Yanchuan, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y Konopleva, Xuhong Cheng, Shao-Cong Sun*.DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B cell leukemogenesis. Blood, (2021) 138 (23): 2360–2371.

2.           Yanchuan Li, Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi, Daniel Lin, Meidi Gu, Xiaofei Zhou, Haiyan S Li, Stephanie S Watowich, Antrix Jain, Sung Yun Jung, Jun Qin, Xuhong Cheng, Shao-Cong Sun*. Preventing Abnormal NF-κB Activation and Autoimmunity by Otub1-Mediated p100 Stabilization. Cell research29, no. 6 (2019): 474.

3.           Yanchuan Li*, Lele Zhu, Chun-Jung Ko, Jin-Young Yang, Ganiraju Manyam, Jing Wang, Xuhong Cheng, Shuli Zhao*, Zuliang Jie*. TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses. Journal of experimental medicine,(2023) 220 (8): e20221483

4.           Lele Zhu, Yanchuan Li, Xiaoping Xie, Xiaofei Zhou, Meidi Gu, Zuliang Jie, Chun-Jung Ko, Tianxiao Gao, Blanca E Hernandez, Xuhong Cheng, Shao-Cong Sun*. TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Nature cell biology, (2019), 21(12): 1604-1614.

5.           Lingyun Zhang, Chun-Jung Ko, Yanchuan Li, Zuliang Jie, Lele Zhu, Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Ting Liu, Xuhong Cheng, Shao-Cong Sun*. Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination. Cell reports 37, no. 4 (2021): 109904.

6.           Jin-Young Yang, Zuliang Jie, Amber Mathews, Xiaofei Zhou, Yanchuan Li, Meidi Gu, Xiaoping Xie, Chun-Jung Ko, Xuhong Cheng, Yuan Qi, Jeannelyn S Estrella, Jing Wang, Shao-Cong Sun*. Intestinal epithelial TBK1 prevents differentiation of T-helper 17 cells and tumorigenesis in mice. Gastroenterology 159, no. 5 (2020): 1793-1806.

7.           Zuliang Jie, Chun-Jung Ko, Hui Wang, Xiaoping Xie, Yanchuan Li, Meidi Gu, Lele Zhu, Jin-Young Yang, Tianxiao Gao, Wenjuan Ru, Shao-Jun Tang, Xuhong Cheng, Shao-Cong Sun*. Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway. Science advances 7, no. 36 (2021): eabh0609.

8.           Zhu, Lele*, Xiaofei Zhou, Meidi Gu, Jiseong Kim, Yanchuan Li, Chun-Jung Ko, Xiaoping Xie, Tianxiao Gao, Xuhong Cheng, Shao-Cong Sun*.Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer. Nature cell biology 24, no. 7 (2022): 1165-1176.

9.           Zuliang Jie, Jin-Young Yang, Meidi Gu, Hui Wang, Xiaoping Xie, Yanchuan Li, Ting Liu, Lele Zhu, Jianhong Shi, Lingyun Zhang, Xiaofei Zhou, Donghyun Joo, Hans D Brightbill, Yingzi Cong, Daniel Lin, Xuhong Cheng, Shao-Cong Sun*. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature immunology 19, no. 11 (2018): 1224-1235.

10.       Gao, Tianxiao, Ting Liu, Chun-Jung Ko, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun*. Myeloid cell TBK1 restricts inflammatory responses. Proceedings of the National Academy of Sciences 119, no. 4 (2022): e2107742119.

 

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2.     热忱欢迎全职博士后加入我们的研究团队。我们希望您已经或即将获得博士学位,并熟练掌握生物化学、分子生物学、免疫学等实验技术。具备免疫学背景者优先考虑。此外,我们希望您在博士期间曾经发表过学术论文,并具备一定的论文撰写、项目申请能力。我们的实验室将为您提供优秀的研究环境和导师的指导,支持您申请科研项目并开展研究工作。如果您满足以上条件并且渴望成为一名优秀的科研人员,我们非常期待您的加入。


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